Mono(6A-N-allylamino-6A-deoxy)perphenylcarbamoylated β-cyclodextrin:: synthesis and application as a chiral stationary phase for HPLC

A novel cyclodextrin derivative: mono(6(A)-N-allylamino-6(A)-deoxy)perphenylcarbamoylated beta-cyclodextrin was synthesized. Hydrosilylation with (EtO)(3)SiH and then reaction of the reactive siloxane with pristine silica gel afforded a facile entry into a durable, structurally well-defined chiral stationary phase capable of enantioseparation of a variety of racemic drugs. (C) 2003 Elsevier Science Ltd. All rights reserved.