期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 6, 页码 1111-1114出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(03)00031-3
关键词
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Using a tetrapeptide-based alpha-ketoamide template, various amines and amino acids were incorporated to explore the prime side of the HCV NS3 protease catalytic site. Glycine carboxylic acid was found to be the most effective prime group. Further optimization yielded an inhibitor with IC50 of 0.060 muM. (C) 2003 Elsevier Science Ltd. All rights reserved.
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