期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 465, 期 1-2, 页码 199-200出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(03)01484-5
关键词
opioid receptor; CaMKII; KN93
It has been reported that Ca2+/calmodulin-dependent protein kinase 11 (CaMKII) can modulate opioid tolerance via its action on learning and memory. In this study, we examine if CaMKII can directly affect opioid tolerance. We found that spinal CaMKII activity was increased in rats tolerant to morphine. In these rats, acute spinal administration of 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine) (KN93), a CaMKII inhibitor, was able to reverse the already-established antinociceptive tolerance. These results suggest that CaMKII may directly promote opioid tolerance. (C) 2003 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据