期刊
LIFE SCIENCES
卷 72, 期 18-19, 页码 2095-2099出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0024-3205(03)00067-5
关键词
acetylcholine; cholinergic receptors; immunohistochemistry
We investigated the occurrence and distribution of the ligand-binding alpha-subunits of nicotinic acetylcholine receptors in the rat arterial system in situ by means of RT-PCR and immunohistochemistry. Except the alpha9-subunit, all other mammalian non-muscular a-subunits were expressed in the arterial wall - either in endothelial or in smooth muscle cells - suggesting it as a direct target of nicotine and endogenous acetylcholine. The distribution pattern of a-subunits found in smooth muscle cells varied considerably among the individual elastic, muscular and intraparenchymal arteries investigated, suggesting that non-neuronal cholinergic signalling via nicotinic receptors in the vascular wall includes components that are highly specific for individual arteries. (C) 2003 Elsevier Science Inc. All rights reserved.
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