期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 23, 期 4, 页码 499-512出版社
SAGE PUBLICATIONS INC
DOI: 10.1097/01.WCB.0000050063.57184.3C
关键词
synchrotron radiation; computed tomography; cerebral blood volume; cerebral blood flow; iodinated contrast agent; partial volume effects
Synchrotron radiation computed tomography opens new fields by using monochromatic x-ray beams. This technique allows one to measure in vivo absolute contrast-agent concentrations with high accuracy and precision, and absolute cerebral blood volume or flow can be derived from these measurements using tracer kinetic methods. The authors injected an intravenous bolus of an iodinated contrast agent in healthy rats, and acquired computed tomography images to follow the temporal evolution of the contrast material in the blood circulation. The first image acquired before iodine infusion was subtracted from the others to obtain computed tomography slices expressed in absolute iodine concentrations. Cerebral blood volume and cerebral blood flow maps were obtained after correction for partial volume effects. Mean cerebral blood volume and flow values (n = 7) were 2.1 +/- 0.38 mL/100 g and 129 +/- 18 mL (.) 100 g(-1) (.) min(-1) in the parietal cortex; and 1.92 +/- 0.32 mL/100 g and 125 +/-17 mL (.) 100 g(-1) (.) min(-1) in the caudate putamen, respectively. synchrotron radiation computed tomography has the potential to assess these two brainperfusion parameters.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据