期刊
JOURNAL OF INFECTIOUS DISEASES
卷 187, 期 7, 页码 1153-1156出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/368345
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Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/ -33C) was overrepresented in patients with CDC (P = .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/ -33T) appeared to be protective against CDC (P = .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.
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