3.8 Article

The force be with you: ATP in gut mechanosensory transduction

期刊

NEWS IN PHYSIOLOGICAL SCIENCES
卷 18, 期 -, 页码 43-49

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AMER PHYSIOLOGICAL SOC
DOI: 10.1152/nips.01411.2002

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资金

  1. NCRR NIH HHS [1S10-RR-11434] Funding Source: Medline
  2. NIDDK NIH HHS [DK-44179-07S1, DK-57016, DK-37240, R01-DK-44179] Funding Source: Medline

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Nucleotides such as ATP and UTP are everywhere. They play a key role in transducing mechanosensory signals via P2Y receptors in the large intestine or colon, leading to secretion of the sensory mediator 5-HT, and act as autocrine, paracrine, or neurocrine mediators in neural reflexes regulating chloride secretion.

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