期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 121, 期 2, 页码 287-295出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04265.x
关键词
B-CLL; Rai stage; FISH; CD38 expression; IgVH mutations
类别
资金
- NCI NIH HHS [CA 95241-01, CA 91542] Funding Source: Medline
Fluorescence in situ hybridization (FISH) was used to detect 6q-, 11q-, +12, 13q-, 17p- and translocations involving 14q32 in interphase nuclei from blood and/or bone marrow from 113 patients with B-cell chronic lymphocytic leukaemia (B-CLL). A total of 87 patients (77%) had a FISH anomaly: 13q- x 1 was most frequent (64%) followed by 13q- x 2 (28%), +12 (25%), 11q- (15%), 17p- (8%) and 6q- (0%). FISH results for blood and bone marrow cells in 38 patients were similar. Purified CD5(+) /CD19(+) cells from blood were studied in eight patients and results indicate that in some patients not all B cells have FISH anomalies. We used a defined set of hierarchical FISH risk categories to compare FISH results by stable versus progressive disease, age, sex, Rai stage, CD38(+) expression and IgV(H) mutational status. Significant differences in FISH risk distributions were associated with Rai stage, disease status and CD38(+) , but not by age, sex or IgV(H) mutational status. To look for baseline factors associated with high-risk disease, multivariate analysis of age, sex, Rai stage, CD38(+) and disease status versus FISH risk category was performed. Importantly, only CD38(+) was significantly associated with high-risk FISH categories (+12, 11q- and 17p-) after adjustment for the effects of other variables.
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