期刊
JOURNAL OF MAGNETIC RESONANCE
卷 161, 期 2, 页码 265-274出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1090-7807(03)00006-5
关键词
in vivo NMR spectroscopy; iZQC; HOMOGENIZED; dipolar demagnetizing field; resolution enhancement
Intermolecular zero-quantum coherences are insensitive to magnetic field inhomogeneities. For this reason we have applied the HOMOGENIZED sequence [Vathyam et al., Science 272 (1996) 92] to phantoms containing metabolites at low concentrations, phantoms with air inclusions, an intact grape, and the head of a rat in vivo at 750 MHz. In the H-1-spectra, the water signal is efficiently suppressed and line broadening due to susceptibility gradients is effectively removed along the indirectly detected dimension. We have obtained a H-1-spectrum of a 2.5 mM solution of gamma-aminobutyric acid in 12 min scan time. In the phantom with air inclusions a reduction of line widths from 0.48 ppm in the direct dimension to 0.07 ppm in the indirect dimension was observed, while in a deshimmed grape the reduction was from 1.4 to 0.07 ppm. In a spectrum of the grape we were able to resolve glucose resonances at 0.3 ppm from the water in 6 min scan time. J-coupling information was partly retained. In the in vivo spectra of the rat brain five major metabolites were observed. (C) 2003 Elsevier Science (USA). All rights reserved.
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