期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 78, 期 3, 页码 289-298出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1023025506386
关键词
array CGH; copy number aberration; genome instability
类别
资金
- NCI NIH HHS [CA58207, CA80314, CA83040, CA84118] Funding Source: Medline
- NICHD NIH HHS [HD17665] Funding Source: Medline
Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.
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