期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 98, 期 3, 页码 407-411出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762003000300021
关键词
Chagas disease cardiomyopathy; tumor necrosis factor-alpha; Trypanosoma cruzi
We compared plasma tumor necrosis factor-alpha (TNF-alpha) levels among asymptomatic/indeterminate Chagas disease patients (ASY) and patients across the clinical spectrum of chronic Chagas disease cardiomyopathy (CCC). Idiopathic dilated cardiomyopathy (DCM) patients and normal controls (NC) were included as controls. ASY Chagas disease patients had significantly higher plasma TNF-alpha levels than NC TNF-alpha levels among severe CCC patients with significant left ventricular (LV) dysfunction were similar to those of DCM patients, showing average 2-fold higher levels than CCC patients without LV dysfunction and ASY patients, and 8-fold higher levels than NC. In Chagas disease, chronic TNF-alpha production prior to heart failure may play a role in CCC progression.
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