期刊
NEUROPSYCHOPHARMACOLOGY
卷 28, 期 4, 页码 651-653出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.npp.1300083
关键词
-
资金
- NIMH NIH HHS [MH62451] Funding Source: Medline
Prepulse inhibition (PPI) of the startle reflex can be disrupted by drugs that act as agonists at the serotonin (5-HT) 2A receptor, such as DOI, and this effect is blocked by drugs that inhibit 5-HT2A transmission. We tested the effects of systemic administration of PD 149 163, a neurotensin agonst, on DOI-induced disruption of PPI in Sprague-Dawley rats. PD 149 163 completely and dose dependently blocked the PPI deficits produced by DOI. These findings suggest that, in addition to their established ability to inhibit dopamine transmission, neurotensin agonists may also inhibit 5-HT2A transmission, a pharmacological feature associated with atypical antipsychotic drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据