期刊
NEUROIMAGE
卷 18, 期 4, 页码 928-937出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1053-8119(03)00042-9
关键词
fMRI; mirror neurons; canonical neurons; parietal cortex; premotor cortex; inferior frontal gyrus
In the macaque monkey ventral premotor cortex (F5), canonical neurones are active when the monkey observes an object and when the monkey grasps that object. In the same area, mirror neurones fire both when the monkey observes another monkey grasping an object and when the monkey grasps that object. We used event-related fMRI to investigate where in the human brain activation can be found that reflects both canonical and mirror neuronal activity. There was activation in the intraparietal and ventral limbs of the precentral sulcus when subjects observed objects and when they executed movements in response to the objects (canonical neurones). There was activation in the dorsal premotor cortex, the intraparietal cortex, the parietal operculum (SII), and the superior temporal sulcus when subjects observed gestures (mirror neurones). Finally, activations in the ventral premotor cortex and inferior frontal gyrus (area 44) were found when subjects imitated gestures and executed movements in response to objects. We suggest that in the human brain, the ventral limb of the precentral sulcus may form part of the area designated F5 in the macaque monkey. It is possible that area 44 forms an anterior part of F5, though anatomical studies suggest that it may be a transitional area between the premotor and prefrontal cortices. (C) 2003 Elsevier Science (USA). All rights reserved.
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