期刊
MAGNETIC RESONANCE IN MEDICINE
卷 49, 期 4, 页码 626-631出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.10412
关键词
glycogenolysis; regulation; H-1 MRS; lactate
资金
- NCRR NIH HHS [5 P41 RR 05964] Funding Source: Medline
Skeletal muscle contraction and glycogenolysis are closely coupled. The standard explanation for this coupling, as taught in modern biochemistry textbooks, is that the metabolic products of contraction (ADP, AMP, P-i) feed back to activate glycogenolytic enzymes, thus providing for resynthesis of ATP. However, both in Vivo P-31 MRS analyses and chemical analyses of muscle extracts have provided results that are contrary to this theory, at least in its simplest form. the MRS studies suffer from ambiguous assumptions. More importantly, in P-31 MRS studies the dependent and independent variables are often confounded because the glycogenolytic rate is calculated from the same data which are used to calculate the other metabolic variables. The analysis of biopsies has been necessarily quite limited, and suffers from a different set of experimental artifacts. Thus, the problem of contraction-glycogenolysis-coupling was reassessed using a quantitatively accurate H-1 MRS method. It is confirmed that glycogenolysis and contractions are closely coupled during repetitive exercise, while glycogenolysis and P-metabolite concentrations are not. A simple metabolic feedback system cannot explain contraction-glycogenolysis-coupling. (C) 2003 Wiley-Liss, Inc.
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