期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 18, 期 2, 页码 211-217出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2003.18.2.211
关键词
beta-catenin; cell adhesion molecules; cyclin D1; mitotic index; immunohistochemistry; liver neoplasms; carcinoma, hepatocellular
Alteration of beta-catenin expression has been implicated in the development of hepatocellular carcinoma (HCC). It has been also reported that beta-catenin can influence the tumor cell proliferation or cyclin D1 expression, one of the target factors of beta-catenin. We performed an immunohistochemical analysis of beta-catenin and cyclin D1 in 77 patients with resected HCCs, and examined the relationships between the expressions of beta-catenin and cyclin D1, and other pathologic parameters including the mitotic index. Altered expressions of beta-catenin including nonnuclear overexpression and nuclear expression were detected in 58.4% of HCCs (45/77) and showed significant correlations with large tumor size, poor histologic grade, and high tumor stage. The mean mitotic index of HCCs with nuclear expression (3.2 +/-3.0) and nonnuclear overexpression (2.7+/-2.5) Was significantly higher than that of tumors with no overexpression (1.7+/-1.4) (p=0.018 and 0.038, respectively), however, no correlation was noted between the expressions of cyclin D1 and beta-catenin. In addition, nonnuclear overexpression out of two altered expression patterns was more frequent (37.7% versus 20.8%) as well as pathologically more significant than nuclear expression. These results indicate that the altered expression of beta-catenin in HCC may play an important role in tumor progression by stimulating tumor cell proliferation, and nonnuclear overexpression may have pathologic significance in HCC.
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