期刊
CELL RESEARCH
卷 13, 期 2, 页码 69-81出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/sj.cr.7290152
关键词
Aurora (Ipl1p); mitosis and cancer
类别
During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis, of human cancer.
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