Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)

The chimeric gene NUP98/HOXC13 was detected in a patient with a cle novo acute myeloid leukemia and a t(11;1 2)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p 15, indicating that the, NUP98 gene was involved in the translocation. At 12q13, the breakpoint fell within BAC578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies. (C) 2003 Wiley-Liss, Inc.