期刊
JOURNAL OF IMMUNOLOGY
卷 170, 期 7, 页码 3799-3805出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.7.3799
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- NHLBI NIH HHS [HL-57492, HL-67674] Funding Source: Medline
- NIAID NIH HHS [T32 AI007290, AI-47822, 5 T32 AI07290, AI-37832] Funding Source: Medline
- NIDDK NIH HHS [DK10022, DK56339] Funding Source: Medline
- NIGMS NIH HHS [GM-37734] Funding Source: Medline
IgA immunoblasts can seed both intestinal and nonintestinal mucosal sites following localized mucosal immunization, an observation that has led to the concept of a common mucosal immune system. In this study, we demonstrate that the mucosae-associated epithelial chemokine, MEC (CCL28), which is expressed by epithelia in diverse mucosal tissues, is selectively chemotactic for IgA Ab-secreting cells (ASC): MEC attracts IgA- but not IgG- or IgM-producing ASC from both intestinal and nonintestinal lymphoid and effector tissues, including the intestines, lungs, and lymph nodes draining the bronchopulmonary tree and oral cavity. In contrast, the small intestinal chemokine, TECK (CCL25), attracts an overlapping subpopulation of IgA ASC concentrated in the small intestines and its draining lymphoid tissues. Surprisingly, T cells from mucosal sites fail to respond to MEC. These findings suggest a broad and unifying role for MEC in the physiology of the mucosal IgA immune system.
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