期刊
GENES CHROMOSOMES & CANCER
卷 36, 期 4, 页码 332-339出版社
WILEY-BLACKWELL
DOI: 10.1002/gcc.10165
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资金
- NCI NIH HHS [CA 88164] Funding Source: Medline
- NCRR NIH HHS [1P41 RR 03655] Funding Source: Medline
Whole-genome scan studies recently identified a locus on chromosome segments 19q 12-q 13.11 linked to prostate tumor aggressiveness by use of the Gleason score as a quantitative trait. We have now completed finer-scale linkage mapping across this region that confirmed and narrowed the candidate region to 2 cM, with a peak between markers D19S87S and D19S433. We also performed allelic imbalance (Al) studies across this region in primary prostate tumors from 52 patients unselected for family history or disease status. A high level of Al was observed, with the highest rates at markers D19S875 (56%) and D19S433 (60%). Furthermore, these two markers defined a smallest common region of Al of 0.8 Mb, with 15 (29%) prostate tumors displaying interstitial Al involving one or both markers. In addition, we noted a positive association between Al at marker D19S87S and extension of tumor beyond the margin (P = 0.02) as well as a higher Gleason score (P = 0.06). These data provide strong evidence that we have mapped a prostate tumor aggressiveness locus to chromosome segments 19q 12-q 13.11 that may play a role in both familial and non-familial forms of prostate cancer. (C) 2003 Wiley-Liss, Inc.
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