期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 62, 期 4, 页码 381-388出版社
AMER ASSN NEUROPATHOLOGISTS INC
DOI: 10.1093/jnen/62.4.381
关键词
ALS/parkinsonism-dementia complex; entorhinal cortex; Guam hippocampus; neurofibrillary tangle
资金
- NIA NIH HHS [AG05138, AG14382] Funding Source: Medline
Since first described, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam has represented an important model Of age-related neurodegenerative disease. ALS/PDC is charactetized neuropathologically by severe widespread in involvement by neurofibrillar tangles (NFTs). Over the past 30 years there has been a dramatic decrease in the incidence of ALS and a 10-year increase in the age of onset of ALS and PDC. In 1979. Anderson et al reported evidence of significant NFT involvement in Guam natives,who had been free of evidence of neurologic dysfunction. Using the slides from this study we re-examined the extent of hippocampus and entorhinal NFT involvement and compared it to brains recently obtained from neurologically intact Guam natives and age-matched controls from New York. The tendency towards hippocampal and entorhinal NFT formation continues, to he encountered among, the inhabitants of Guam, particulary among those over age 50, although severe involvement was less commonly noted in relatively young individuals (<50 years). As noted by Anderson et al. the pattern of neuropathologic lesions seen in those with extensive NFT involvement suggests that such cases represent preclinical examples of ALS/PDC in individuals who hake et to accumulate a sufficient burden of pathology to attract clinical attention and diagnostic evaluation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据