期刊
IUBMB LIFE
卷 55, 期 4-5, 页码 267-271出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/1521654031000121666
关键词
dopamine; MPTP; neuronal death; c-Jun amino-terminal kinases; Parkinson's disease
Given the critical role that the c-Jun N-terminal kinase (JNK) pathway plays in regulating many of the cellular processes which are affected in Parkinson's disease (PD), the possible importance of JNK in disease pathogenesis is being increasingly recognized. Here we review recent findings implicating the JNK signaling pathway in animal models of Parkinson's disease and discuss the relationship between this pathway and the prominent pathological processes observed in the disease state. We suggest that regulation of the JNK signaling pathway may be a central facet in potential treatments for the disease.
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