期刊
ARTIFICIAL ORGANS
卷 34, 期 4, 页码 311-318出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1525-1594.2009.00858.x
关键词
Calcification; Cardiac valves; Bioprostheses; Hydroxyapatite; X-ray absorption near edge structure
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Calcification is the most common cause of damage and subsequent failure of heart valves. Although it is a common phenomenon, little is known about it, and less about the inorganic phase obtained from this type of calcification. This article describes the scanning electron microscopy (SEM)/energy dispersive X-ray spectroscopy and Ca K-edge X-ray absorption near edge structure (XANES) characterization performed in natural and bioprosthetic heart valves calcified in vivo (in comparison to in vitro-calcified valves). SEM micrographs indicated the presence of deposits of similar morphology, and XANES results indicate, at a molecular level, that the calcification mechanism of both types of valves are probably similar, resulting in formation of poorly crystalline hydroxyapatite deposits, with Ca/P ratios that increase with time, depending on the maturation state. These findings may contribute to the search for long-term efficient anticalcification treatments.
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