期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 51, 期 4, 页码 545-548出版社
HISTOCHEMICAL SOC INC
DOI: 10.1177/002215540305100417
关键词
Russell bodies; aggresomes; ER; CFTR; BiP; chaperone; yeast; ERAD
类别
资金
- NIDDK NIH HHS [DK60385-01] Funding Source: Medline
Almost all secreted proteins pass through the endoplasmic reticulum (ER), an organelle that is equipped to tolerate and/or degrade misfolded proteins. We report here that yeast expressing the cystic fibrosis transmembrane conductance regulator (CFTR) concentrate the protein at defined sites in the ER membrane that are not necessarily enriched for the ER molecular chaperone BiP. We propose that these sites are Russell bodies, an ER subcompartment in which misfolded proteins are stored and can be targeted for degradation.
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