期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 111, 期 4, 页码 661-675出版社
MOSBY-ELSEVIER
DOI: 10.1067/mai.2003.162
关键词
asthma; risk factors; wheezing syndromes; atopy; lower respiratory tract illnesses; Tucson Children's Respiratory Study; lung function; immunology
资金
- NHLBI NIH HHS [HL14136, HL03154, HL56177] Funding Source: Medline
The Tucson Children's Respiratory Study (TCRS), begun in 1980, has followed 1246 subjects from birth together with their family members to delineate the complex interrelationships between a large number of potential risk factors, acute lower respiratory tract illnesses, and chronic lung disorders later in childhood and early adult life, especially asthma. Nine hundred seventy-four (78%) of the original subjects are still being followed. Among its numerous findings, the TCRS has (1) described various wheezing disorders (transient, nonatopic, atopic) and their characteristics; (2) developed an Asthma Predictive Index; (3) delineated the respiratory and atopic outcomes for children who had respiratory syncytial virus-related wheezing illnesses in infancy; and (4) evaluated a large number of risk factors for acute respiratory tract illnesses during the first 3 years of life. Future TCRS studies will focus on (1) factors in infancy and early childhood that relate to persistent asthma and atopy; (2) role of genetic factors in persistent asthma; and (3) determinants of lung function decline in early adult life.
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