期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 7, 期 2, 页码 113-126出版社
CAROL DAVILA UNIV PRESS
DOI: 10.1111/j.1582-4934.2003.tb00210.x
关键词
polyamines; cancer; ornithine decarboxylase
资金
- NCI NIH HHS [CA73058, CA80163, CA42439] Funding Source: Medline
- NIEHS NIH HHS [ES05022] Funding Source: Medline
Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine synthase, and spermine synthase. The catabolic enzymes include spermidine/spermine acetyltransferase, flavin containing polyamine oxidase, copper containing diamine oxidase, and possibly other amine oxidases. Multiple abnormalities in the control of polyamine metabolism and uptake might be responsible for increased levels of polyamines in cancer cells as compared to that of normal cells. This review is designed to look at the current research in polyamine biosynthesis, catabolism, and transport pathways, enumerate the functions of polyamines, and assess the potential for using polyamine metabolism or function as targets for cancer therapy.
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