期刊
JOURNAL OF BIOSCIENCES
卷 28, 期 3, 页码 311-321出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/BF02970150
关键词
ER stress; hepatitis B virus; hepatitis C virus; NF-kappa B; oxidative stress; STAT-3
类别
Of all the hepatitis viruses, only the hepatitis B virus (HBV) and hepatitis C virus (HCV) cause chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. In this review, we discuss how these two biologically diverse viruses use common pathways to induce oxidative stress and activation of key transcription factors, known to be involved in inflammatory processes in cells. Activation of NF-kappaB and STAT-3 most likely contribute to the progression of viral infections to chronic hepatitis and liver oncogenesis associated with HBV and HCV infections. In this review, we focus on the mechanisms of action of HBx and HCV NS5A proteins in inducing intracellular events associated with the viral infections.
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