期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 31, 期 -, 页码 318-325出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0310318
关键词
biosynthesis of glycoproteins; inflammation; O-glycan; mucin; sulphotransferase
This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro, it is still difficult to determine exactly which enzymes are responsible for mucin sulphation in vivo. Sulphotransferases play a critical role in determining the chemical, physical and biological properties of mucins. Several of these enzymes have been shown to differ in expression and activity in cancer and inflammation.
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