期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 8, 页码 1289-1292出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm034007d
关键词
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The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data indicating that this scaffold is a promising lead for the development of specific inhibitors of endothelial cell proliferation.
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