期刊
NEUROSCIENCE LETTERS
卷 340, 期 2, 页码 115-118出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00072-7
关键词
glutamate dehydrogenase; vigabatrin; seizure; gerbil; epilepsy; hippocampus
Vigabatrin (VGB, gamma-vinyl-gamma-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the seizure prone gerbil hippocampus after treating VGB were investigated to identify the effect of VGB on energy and/or glutamate metabolism via GDH. In the VGB treated group, GDH immunoreactivity and its activity in the hippocampus were significantly decreased, as compared with those of controls. These findings suggest that VGB administration may suppress the development and spread of seizures not only by elevating the level of GABA, but also by affecting the glutamate signaling and energy metabolism in neurons. (C) 2003 Elsevier Science Ireland Ltd. All fights reserved.
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