期刊
TETRAHEDRON
卷 59, 期 16, 页码 2855-2859出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(03)00335-1
关键词
ascidian; didemnid; alkaloids; lissoclinotoxins E and F; computational chemistry; cytotoxicity; PTEN; MDA-MB-468; MDA-MB-4355
Bioassay-guided fractionation of the MeOH extract from a Philippine didemnid ascidian resulted in the isolation of two new dimeric alkaloids, lissoclinotoxins E (1) and F (2). The polysulfide structures for compounds 1 and 2 were determined by interpretation of spectroscopic data and chemical degradation. Computational chemistry studies suggested that the N-alkyl chains about the tricyclic systems of lissoclinotoxins E and F had trans and cis orientations, respectively. Alkaloids 1 and 2 displayed IC50 values of 2.3 and 1.5 mug/mL, respectively, towards the PTEN-deficient human breast carcinoma cell line, MDA-MB-468. (C) 2003 Elsevier Science Ltd. All rights reserved.
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