期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 208, 期 1-2, 页码 71-78出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-510X(02)00438-0
关键词
cerebral blood flow; orthostatic hypotension; Doppler; middle cerebral artery; impedance cardiography; spectral analysis; cerebral autoregulation
The aim of this study was to determine whether lower body negative pressure (LBNP), combined with noninvasive methods of assessing changes in systemic and cerebral vascular resistance, is suitable as a method for assessing cerebral autoregulation. In 13 subjects we continuously assessed heart rate, blood pressure, cerebral blood flow velocity (CBFV) and cardiac output during graded levels of LBNP from 0 to - 50 mm Hg. With increasing levels of LBNP, cardiac output declined significantly (to 55.8 +/- 4.5% of baseline value) but there was no overall change in mean arterial pressure. CBFV also fell at higher levels of LBNP (to 81.4 +/- 3.2% of baseline) but the percentage CBFV change was significantly less than that in cardiac output (P < 0.01). The maximum increase in cerebrovascular resistance (pulsatility ratio) was significantly less than that in total peripheral resistance (17 +/- 6% vs. 105 +/- 16%, P < 0.01). Spectral analysis showed that the power of low-frequency oscillations in mean arterial pressure, but not CBFV, increased significantly at the - 50 mm Hg level of LBNP. These results show that, even during high levels of orthostatic stress, cerebral autoregulation is preserved and continues to protect the cerebral circulation from changes in the systemic circulation. Furthermore, assessment of cardiovascular and cerebrovascular parameters during LBNP may provide a useful clinical test of cerebral autoregulation. (C) 2002 Elsevier Science B.V. All rights reserved.
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