期刊
SCIENCE
卷 300, 期 5618, 页码 498-502出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1082163
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资金
- NINDS NIH HHS [NS-38416, NS-10414] Funding Source: Medline
The mammalian auditory cortex normally undergoes rapid and progressive functional maturation. Here we show that rearing infant rat pups in continuous, moderate-level noise delayed the emergence of adultlike topographic representational order and the refinement of response selectivity in the primary auditory cortex (A1) long beyond normal developmental benchmarks. When those noise-reared adult rats were subsequently exposed to a pulsed pure-tone stimulus, A1 rapidly reorganized, demonstrating that exposure-driven plasticity characteristic of the critical period was still ongoing. These results demonstrate that A1 organization is shaped by a young animal's exposure to salient, structured acoustic inputs-and implicate noise as a risk factor for abnormal child development.
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