期刊
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
卷 38, 期 1, 页码 52-56出版社
INFORMA HEALTHCARE
DOI: 10.3109/10731190903495785
关键词
Leukotriene B4; osteoclast; TRAP staining; differentiation
资金
- Major State Basic Research Development Program of China [2002CB513007]
Our previous study showed that Leukotriene B4 can directly stimulate osteoclast differentiation independent of RANKL. In order to determine whether Leukotriene B4 could indirectly stimulate human osteoclast differentiation through increasing RANKL expression of rheumatoid arthritis fibroblast-like synoviocytes, we utilize the coculture model of rheumatoid arthritis fibroblast-like synoviocytes and monocyte, which were stimulated in the presence of 2.5ng/ml M-CSF in the control group, 2.5ng/ml M-CSF+10
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