期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 459, 期 1, 页码 1-8出版社
WILEY-LISS
DOI: 10.1002/cne.10593
关键词
axon regeneration; spinal cord injury; sprouting; tract tracing
Several recent studies report that axon regeneration can be induced in the mature mammalian nervous system by novel treatments or genetic manipulations. In assessing these reports, it is important to be mindful of the history of regeneration research, which is littered with the corpses of studies that reported regeneration that later proved incorrect. One important reason is the spared axon conundrum, in which axons that survive a lesion are mistakenly identified as having regenerated. Here, we illustrate the problem and propose criteria that may be used to identify regenerated vs. spared axons, focusing on the injured spinal cord. (C) 2003 Wiley-Liss, Inc.
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