期刊
TETRAHEDRON LETTERS
卷 44, 期 17, 页码 3471-3475出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)00671-3
关键词
alkaloid; Didemnum; fascaplysin; Fascaplysinopsis; sponge; tunicate
The structural variations and bioactivity properties of the alkaloids in the fascaplysin (1) and the reticulatine (3) families were examined. Four organisms were analyzed consisting of two collections of the sponge Fascaplysinopsis reticulata and two collections of the tunicate Didemnum sp. Reported are the isolation of three new compounds: 3-bromofascaplysin (2), 14-bromoreticulatine (4), and 14-bromoreticulatate (6) along with reticulatate (5) previously known as a semi-synthetic product of 1. Compounds I and 5 showed selectivity in a cell based cytotoxicity assay. (C) 2003 Elsevier Science Ltd. All rights reserved.
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