期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 197, 期 8, 页码 1007-1016出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20021812
关键词
major histocompatibility complex; CD4-positive T lymphocytes; immunological memory; T cell receptor
资金
- Wellcome Trust Funding Source: Medline
The requirements for survival and self-renewal of peripheral T cells and the nature of mechanisms controlling the size of the naive and memory pool are not completely understood. Here, we examine the involvement of the major histocompatibility complex (MHC) in survival and homeostatic expansion of naive and memory T cells. We show that the homeostatic behavior of naive T cell receptor (TCR)-transgenic T cells can be deduced by the expression levels of TCR and CD5, a negative regulator of TCR signaling. Both these factors determine the strength of TCR stimulation by MHC-derived signals. We further show that, similarly to naive T cells, MHC-derived signals influence the homeostatic expansion capacity of memory T cells under lymphopenic conditions. In contrast to naive T cells, however, memory T cells can reach a homeostatic equilibrium, in which survival/self-renewal of each clone is dissociated from their avidity for MHC-derived signals.
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