Solubilities of phenazopyridine, propranolol, and methimazole in supercritical carbon dioxide

The equilibrium solubilities of three drugs (phenazopyridine, propranolol and methimazole) were determined at temperatures ranging from 308 to 348 K and pressures from 122 to 355 bar in supercritical CO2 by a simple and reliable static method. The crossover region was observed for phenazopyridine, propranolol and methimazole at 180 bar. The solubilities were correlated using a semi empirical model. Correlation of the results shows good self-consistency of the data obtained. (C) 2003 Elsevier Science B.V. All rights reserved.