期刊
FEBS LETTERS
卷 541, 期 1-3, 页码 57-63出版社
WILEY
DOI: 10.1016/S0014-5793(03)00299-0
关键词
apoptosis; Bcr-Abl; Bcl-2; Bcl-X-L; mitochondrion
Ectopic expression of Bcr-Abl, Bcl-2 or Bcl-x(L) in HL-60 cells conferred resistance to apoptosis against a variety of death-inducing agents. Bcr-Abl-mediated interference with mitochondrial events was confirmed by the analysis of the loss of mitochondrial transmembrane potential and cytochrome c release. RL-60.Bcr-Abl cells were extremely resistant to all apoptogenic stimuli tested, even in circumstances where HL-60.Bcl-2 or HL-60.Bcl-x(L) cells were only partially protected from apoptosis. The levels of Mcl-1, Bax, Bid, Akt, c-IAP-1, c-IAP-2, XIAP and c-FLIP were compared in all HL-60 lines. Our findings show that Bcr-Abl is a more powerful anti-apoptotic molecule than Bcl-2 or Bcl-x(L). (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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