期刊
JOURNAL OF CONTROLLED RELEASE
卷 89, 期 2, 页码 199-212出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(03)00033-6
关键词
dissolution profiles comparisons; model dependent methods; model independent methods; mean dissolution times; fit factors; correlation coefficients
In this work we use both model dependent and independent techniques to assess the difference between dissolution profiles in which ibuprofen, in the form of uncoated pellets, is used as a model drug. The choice of a proper regression function, the relevance of the estimated parameters and the influence of the choice of dissolution points in the assessment of differences is discussed. The results obtained via mean dissolution times (MDT) and fit-factors (f(1) and f(2)) are also discussed and a non-quantitative method based on profiles correlation with graphical representation (concentration vs. concentration and rate vs. rate) presented. The tested methods discriminate similarly between curves, although not in all cases, but those based on modeling. MDT and fit-factors have shown to be less informative than the correlation approach. (C) 2003 Elsevier Science B.V. All rights reserved.
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