期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
卷 358, 期 1432, 页码 649-655出版社
ROYAL SOC LONDON
DOI: 10.1098/rstb.2002.1255
关键词
long-term depression; metaplasticity; visual cortex; ocular dominance plasticity; Hebb; Bienenstock-Cooper-Munro (BCM) theory
类别
Theories of receptive field plasticity and information storage make specific assumptions for how synapses are modified. I give a personal account of how testing the validity of these assumptions eventually led to a detailed understanding of long-term depression and metaplasticity in hippocampal area CA1 and the visual cortex. The knowledge of these molecular mechanisms now promises to reveal when and how sensory experience modifies synapses in the cerebral cortex.
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