期刊
INFECTION AND IMMUNITY
卷 71, 期 5, 页码 2885-2891出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.5.2885-2891.2003
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资金
- NIAID NIH HHS [AI-32991] Funding Source: Medline
- NIDDK NIH HHS [DK-58536, R01 DK058536] Funding Source: Medline
Salmonella enterica serovar Typhimurium can infect epithelial cells via the basolateral surface after breaching the intestinal epithelium, yet little is known about this process. Here, we show that actin polymerization driven by the Arp2/3 complex is critical to both basolateral and apical bacterial invasion of polarized MDCK cells. While there is also a dependence upon toxin B-sensitive Rho GTPases, none of the four GTPases known to be activated by S. enterica serovar Typhimurium SopE are individually required for basolateral internalization. These results underscore that the specific factors required for Salmonella invasion differ between membrane domains of polarized epithelia.
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