期刊
JOURNAL OF NATURAL PRODUCTS
卷 66, 期 5, 页码 722-724出版社
AMER CHEMICAL SOC
DOI: 10.1021/np020513e
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The aerial parts of Nanodea muscosa, collected in Chile, yielded two new acetylenic acids. Their structures were elucidated by spectroscopic analyses, including 2D NMR techniques, as (13E)-octadec-13-en-11-ynoic acid (1) and (2E)-octadee-2-en-4-ynedioic acid (2). Compound 2 constitutes the first example of a conjugated ene-yne fatty diacid isolated from a natural source. Compounds 1 and 2 did not exhibit toxicity toward a panel of DNA damage checkpoint defective yeast mutants or show affinity for the 5-HT1A, 5-HT2A, D-2, and H-1 receptors.
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