期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 7, 期 3, 页码 285-288出版社
AMER CHEMICAL SOC
DOI: 10.1021/op0340208
关键词
-
This report describes a scalable process for the asymmetric synthesis of (R)-2-aniino-1-(3-pyridinyl)ethanol dihydrochloride. The stereochemistry of the product is set via a reduction of 3-chloroacetyl pyridine with 2 equiv of borane-dimethyl sulfide and a catalytic amount of an in situ generated oxazaborolidine. The enantiomeric excess (ee) of the reductive step depends on the addition rate of the substrate and the temperature. The authors hypothesize that the low ee observed during a fast addition of the substrate or at low temperatures is due to the slow regeneration of the active catalyst from the catalyst-product complex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据