期刊
JOURNAL OF IMMUNOLOGY
卷 170, 期 9, 页码 4432-4436出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.9.4432
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资金
- NHLBI NIH HHS [R37 HL079142, R01 HL061271, R01 HL079142, R01 HL079142-01, R01HL061271-04] Funding Source: Medline
- NIAAA NIH HHS [P50 AA009803, P50AA009803] Funding Source: Medline
- NIAID NIH HHS [R01 AI051677, R01AI051677] Funding Source: Medline
Local production of IL-17 is a significant factor in effective host defense against Gram-negative bacteria. However, the proximal events mediating IL-17 elaboration by Tcells remain unclear. In this study, we show in vivo that intact Toll-like receptor 4 signaling in the lung is required for induction of both the p19 transcript of IL-23 and IL-17 protein elaboration in response to Klebsiella pneumoniae. Although IL-17 is widely considered a CD4(+) T cell product, we also demonstrate significant in vitro IL-17 production by CD8(+) T cells after culture in medium from dendritic cells exposed to these bacteria. The dominant portion of this IL-17-inducing activity for both CD4(+) and CD8(+) T cells is IL-23. These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8(+) T cell IL-17 production.
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