期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 4, 期 5, 页码 373-384出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1105
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Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.
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