期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 284, 期 5, 页码 G734-G738出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00491.2002
关键词
Fas; tumor necrosis factor-associated apoptosis-inducing ligand; Bid
资金
- NIDDK NIH HHS [DK-41876] Funding Source: Medline
Toxic bile acids facilitate Fas and tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) death-receptor oligomerization and activation. Bile acid modulation of death-receptor signaling is multifactorial and includes trafficking of Fas to the cell surface, enhancing TRAIL-R2/DR5 expression, and suppression of function of cFLIP, an antiapoptotic protein modulating death-receptor function. Because bile acid-associated death receptor-mediated apoptosis is a common mechanism for cholestatic hepatocyte injury, inhibition of death receptors and their cascades may prove useful in attenuating liver injury during cholestasis.
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