期刊
GENE EXPRESSION PATTERNS
卷 3, 期 2, 页码 131-134出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-133X(03)00012-7
关键词
TAK1; mouse embryo; immunohistochemistry; nervous system; testis; kidney; liver; gut; lung; pancreas
资金
- NICHD NIH HHS [2T32-HD07480-06] Funding Source: Medline
TGF-beta activated kinase I (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-beta (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development. (C) 2003 Elsevier Science B.V. All rights reserved.
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