期刊
NATURE REVIEWS IMMUNOLOGY
卷 3, 期 5, 页码 361-370出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1083
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Granule exocytosis is the main pathway for the immune elimination of virus-infected cells and tumour cells by cytotoxic T lymphocytes and natural killer cells. After target-cell recognition, release of the cytotoxic granule contents into the immunological synapse formed between the killer cell and its target induces apoptosis. The granules contain two membrane-perturbing proteins, perforin and granulysin, and a family of serine proteases known as granzymes, complexed with the proteoglycan serglycin. In this review, I discuss recent insights into the mechanisms of granule-mediated cytotoxicity, focusing on how granzymes A, Band C and granulysin activate cell death through caspase-independent pathways.
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