期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 33, 期 5, 页码 1193-1204出版社
WILEY
DOI: 10.1002/eji.200323790
关键词
B cell; antibody; Th subset; regulatory T cell; fungus
类别
资金
- NIAID NIH HHS [R01 AI24912, P01 AI37194] Funding Source: Medline
Protective immunity to Candida albicans and Aspergillus fumigatus is mediated by antigen-specific Th1 cells. To define the role of B cells and antibodies in the generation of antifungal immune resistance, B cell-deficient (muMT) mice were assessed for immune resistance to primary and secondary infections with both fungi. The results showed that, although passive administration of antibodies increased the fungal clearance, the innate and Th1-mediated resistance to the primary and secondary infections were both heightened in muMT mice with candidiasis and aspergillosis. However, although capable of efficiently restricting the fungal growth, muMT mice did not survive the re-infection with C. albicans, and this was concurrent with the failure to generate IL-10-producing dendritic cells and regulatory CD4(+)CD25(+) T cells. Antifungal opsonizing antibodies restored IL-10 production by dendritic cells from muMT mice, a finding suggesting that the availability of opsonizing antibodies may condition the nature of the dendritic cell interaction with fungi, possibly impacting on the development of long-lasting antifungal immunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据