期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 132, 期 2, 页码 209-215出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2249.2003.02151.x
关键词
dermatitis; gamma/delta TCR; mice; Staphylococcus aureus
类别
The high number of gamma /delta -expressing T cells found in the epithelial lining layer suggests that they form a first line of defence against invading pathogens. To evaluate the role of gamma /delta T cell-receptor (TCR)-expressing cells in cutaneous infection caused by Staphylococcus aureus , mice lacking gamma /delta -expressing T cells (TCRdelta(-/-) ) were inoculated intradermally with S. aureus, and compared with S. aureus -infected congeneic TCRdelta(+/-) control mice. The number of bacteria recovered from the skin of TCRdelta(-/-) mice was significantly higher (P = 0.0071) at early time-points after inoculation compared to the number of bacteria isolated from infected TCRdelta(+/) - congeneic controls. Nevertheless, inflammatory responses measured as serum IL-6 levels, were significantly lower in TCRdelta(-/-) mice than in the control group. A possible explanation for this discrepancy was the observation of significantly decreased overall numbers of infiltrating cutaneous T lymphocytes, which are important producers of IL-6. These results support the notion that the gamma /delta -expressing T cells that reside at the epithelial lining layer of the skin is of importance for early containment of the bacteria, thereby limiting their replication and spread.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据